Exercise Intolerance in Older HFPEF Patients
Description: PUBLIC HEALTH RELEVANCE: Exercise intolerance (reduced peak VO2) is the main symptom of heart failure with preserved ejection fraction (HFpEF), the most common form of HF in older persons. Our recent study showed that dietary weight loss plus aerobic exercise significantly improves peak VO2 in HFpEF, but loss of muscle mass also occurred, a concern for efficacy and long-term outcomes. The proposed study will test whether the addition of resistance training will further increase peak VO2 by increasing muscle mass and mitochondrial function, thus improving quality-of-life for the 85% (1.8 million) of older HFpEF patients in the community who are overweight/obese.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2001-02-15
End date: 2023-03-31
Investigator: DALANE W KITZMAN
Institution: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 240
Funder award ID: R01AG018915
OpenAlex ID: G4484359279