Significance of metabolic activation of lumisterol in the skin
Description: Following the surprising discovery that lumisterol, previously believed to be metabolically inactive, is transformed by CYP11A1 to biologically active hydroxy-derivatives which are detectable in the human serum and epidermis, we will define functions of these products in the skin using a highly mechanistic approach. This will include investigation on the mechanism of action of the derivatives, focusing on RORα and γ signaling. We will define their roles in the keratinocyte differentiation program and test them as protectors of genomic and cellular integrity in the epidermis against UVB, the UVR spectrum responsible for the production of lumisterol.
Funding type: research
Funder scheme: R01
Start date: 2017-09-01
End date: 2023-08-31
Investigator: ANDRZEJ T SLOMINSKI
Institution: UNIVERSITY OF ALABAMA AT BIRMINGHAM
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 116
Funder award ID: R01AR071189
OpenAlex ID: G5572293889