Mitochondrial Stress Signal Transduction from Organelle to Organism
Description: NARRATIVE Mitochondria communicate with the nucleus where they drive specific gene expression programs, and recent studies indicate that this signal transduction system is governed by mitochondrial network organization, fusion/fission dynamics, and mitochondrial proximity to the nucleus. I propose the use of novel inducible inter- organellar linkers, and genetic manipulation of mitochondrial network morphology, to test the role of mito-mito and mito-nuclear interactions on nuclear transcriptional responses patterns. I propose to test these mechanisms in muscle cells, and possibly in other systems, where mitochondrial defects contribute to stress pathophysiology.
Funding type: research
Funder scheme: R35
Start date: 2016-09-01
End date: 2021-05-31
Investigator: MARTIN PICARD
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 42
Funder award ID: R35GM119793
OpenAlex ID: G8936651313