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Dissecting the aging of hematopoietic stem cells by genetic tracing in vivo

Description: PUBLIC HEALTH RELEVANCE: The proposed work is focused on the aging of hematopoietic stem cells (HSCs), which maintain constant blood production throughout life. Using a novel approach to the study of HSCs in intact organisms, we will characterize the function of HSCs during aging. The results may help elucidate the mechanisms of blood production abnormalities in the elderly, and pave the way for their therapeutic correction.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2015-01-15

End date: 2020-12-31

Investigator: BORIS REIZIS

Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 11

Funder award ID: R01AG049074

OpenAlex ID: G6544450656

Stem cell decoupling underlies impaired lymphoid development during aging

2023 · Geunhyo Jang, Stephania Contreras Castillo, et al. · Proceedings of the National Academy of Sciences · 15

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

2022 · Jue Feng, Joseph N. Pucella, et al. · Immunity · 106

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

2021 · María Casanova-Acebes, Erica Dalla, et al. · Nature · 603

Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche

2020 · Samik Upadhaya, Oleg Krichevsky, et al. · Cell stem cell · 73

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

2020 · Joseph N. Pucella, Samik Upadhaya, et al. · Annual Review of Cell and Developmental Biology · 53

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

2020 · Basak B. Ural, Stephen T. Yeung, et al. · Science Immunology · 287

Kinetics of adult hematopoietic stem cell differentiation in vivo

2018 · Samik Upadhaya, Catherine M. Sawai, et al. · The Journal of Experimental Medicine · 89

Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells

2018 · Colleen M. Lau, Ioanna Tiniakou, et al. · The Journal of Experimental Medicine · 43

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells

2018 · Margaret E. Kirkling, Urszula Cytlak, et al. · Cell Reports · 207

New genetic tools for the in vivo study of hematopoietic stem cell function

2018 · Samik Upadhaya, Boris Reizis, et al. · Experimental Hematology · 15

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

2016 · Catherine M. Sawai, Sonja Babovic, et al. · Immunity · 381