Role of CD38 in NAD metabolism: from the basic biology of aging to translation
Description: Project Narrative: Old age is the number one risk factor for many diseases including diabetes, loss of muscle function, and cancers. As the world population ages, the incidence of these conditions will further increase. Much is still not known about how aging leads to the development of these diseases. We believe that increased degradation of the essential nucleotide nicotinamide adenine dinucleotide (NAD) by the enzyme CD38 may be the common underlying element in many age-related metabolic dysfunctions. Thus, our studies to understand what drives these cellular metabolic changes may lead to the development of therapies for multiple types of age-related diseases.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2018-06-01
End date: 2025-02-28
Investigator: EDUARDO N CHINI
Institution: MAYO CLINIC JACKSONVILLE
Subfield: Physiology
Domain: Life Sciences
Funded outputs count: 42
Funder award ID: R01AG058812
OpenAlex ID: G5671830567