Inflammatory Pathways in Aortic Aneurysms
Description: PUBLIC HEALTH RELEVANCE: Abdominal aortic aneurysms (AAA) are age-associated, life-threatening dilations of the abdominal aorta that are associated with a proteolytic and inflammatory remodeling of the vascular wall. No drugs have yet proven effective in preventing or limiting human AAA growth and this makes AAAs one of the few cardiovascular disorders for which there is no pharmacological therapy. Here we propose to investigate the role and the therapeutic potential of a new non-canonical Wnt signaling axis in the setting of AAA.
Funding type: research
Funder scheme: R01
Start date: 2016-04-01
End date: 2020-03-31
Investigator: KENNETH WALSH
Institution: UNIVERSITY OF VIRGINIA
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 22
Funder award ID: R01HL132564
OpenAlex ID: G7758052562