Exploring the Innate Sensors Underlying Cancer Immunosurveillance
Description: Project Narrative Despite the recent advancements in immunotherapy, there are still many cancer patients who remain unresponsive to treatment. While it is widely thought that infiltration of tumor by tumor- specific CD8+ T cells predicts clinical responses, it is still unknown which characteristics of cancer are detected by the host immune system to prime T cells and generate an inflamed tumor microenvironment. By elucidating the innate immune mechanisms that underlie cancer immunosurveillance leading to spontaneous tumor rejection, this project will help uncover novel therapeutic strategies to convert “cold” tumors into “hot” ones that can subsequently be targeted by checkpoint inhibition.
Funder: National Cancer Institute
Funding type: fellowship
Funder scheme: F30
Start date: 2019-01-01
End date: 2021-12-31
Investigator: DANIEL J KIM
Institution: YALE UNIVERSITY
Funded outputs count: 6
Funder award ID: F30CA236466
OpenAlex ID: G3468095587