Viable Microvessels for the Study of the Microvasculature in Alzheimer's Disease
Description: Viable human brain microvessels (MV) provide a novel opportunity to examine anatomic and functional changes related to Alzheimer’s Disease (AD) and, more importantly, test the effect of interventions that have therapeutic implications. We find that MV freshly isolated from the brains of recently deceased human subjects with and without dementia are viable for up to 10 days in 3D matrix. The goal of this grant is to use these viable MV to determine cellular and biochemical fidelity to their original donor MV and brain tissues, and to define the MV response to pericyte depletion.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2021-08-15
End date: 2024-05-31
Investigator: MAY J REED
Institution: UNIVERSITY OF WASHINGTON
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 9
Funder award ID: R21AG073676
OpenAlex ID: G8568858603