Molecular regulation of immunoproteasome assembly in inflammatory diseases
Description: An excessive inflammatory response is associated with uncontrolled local and systemic inflammation during severe gram-negative bacterial infections, resulting in cell death and tissue damage. These studies will be the first to elucidate a pro-inflammatory role of inducible immunoproteasome structural assembly in gram-negative bacterial infection-induced acute inflammatory response. These studies will be critical in development of novel therapeutics by inhibition of USP14 or the immunoproteasome to diminish pro-inflammatory responses in acute respiratory distress syndrome (ARDS) and other lethal systemic inflammatory diseases.
Funding type: research
Funder scheme: R01
Start date: 2023-07-01
End date: 2027-06-30
Investigator: JING ZHAO
Institution: OHIO STATE UNIVERSITY
Funded outputs count: 20
Funder award ID: R01HL167846
OpenAlex ID: G9000876433