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Traumatic Stress and Accelerated Aging in DNA Methylation

Description: PUBLIC HEALTH RELEVANCE: Recent advances in molecular medicine have yielded new insight into the cellular mechanisms underlying biological aging and have suggested that DNA methylation profiles are a reliable index of cellular age; new algorithms for estimating DNA methylation age open the door for studying the environmental factors that may impact the rate of aging. We propose to test if trauma exposure and posttraumatic stress disorder (PTSD) are associated with accelerated cellular aging in DNA methylation and to examine if accelerated cellular aging underlies the common co-occurrence of PTSD with metabolic syndrome. In so doing, we hope to better understand PTSD-related disease and help identify those who are at greatest risk for accelerated aging and its negative health consequences.
Funding type: research
Funder scheme: R03
Start date: 2016-04-15
End date: 2019-03-31
Investigator: ERIKA J WOLF
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Funded outputs count: 21
Funder award ID: R03AG051877
OpenAlex ID: G7507267629
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
2024 · Seyma Katrinli, Agaz H. Wani, et al. · Genome Medicine · 28
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Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts
2024 · Seyma Katrinli, Agaz H Wani, et al. · medRxiv · 2
PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L
2020 · Seyma Katrinli, Yuanchao Zheng, et al. · Brain Behavior and Immunity · 37
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation
2020 · Erika J. Wolf, Mark W. Logue, et al. · Psychoneuroendocrinology · 18
An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
2020 · the Traumatic Stress Brain Study Group, Mark W. Logue, et al. · Clinical Epigenetics · 102
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Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
2019 · Sandro Marini, Kathryn A. Davis, et al. · Psychoneuroendocrinology · 140
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Correction for Multiple Testing in Candidate-Gene Methylation Studies
2019 · Zhenwei Zhou, Kathryn L Lunetta, et al. · Epigenomics · 9
Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome
2019 · Filomene G. Morrison, Mark W. Logue, et al. · Aging · 35
The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging
2019 · Erika J. Wolf, Filomene G. Morrison, et al. · Brain Behavior and Immunity · 42
DNA methylation correlates of PTSD: Recent findings and technical challenges
2018 · Filomene G. Morrison, Mark W. Miller, et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 52
Posttraumatic Stress Disorder Symptoms, Temperament, and the Pathway to Cellular Senescence
2018 · Samantha L. Connolly, Tawni B. Stoop, et al. · Journal of Traumatic Stress · 15
Posttraumatic psychopathology and the pace of the epigenetic clock: a longitudinal investigation
2018 · Erika J. Wolf, Mark W. Logue, et al. · Psychological Medicine · 72
Traumatic stress and accelerated DNA methylation age: A meta-analysis
2017 · Erika J. Wolf, Hannah Maniates, et al. · Psychoneuroendocrinology · 245
CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein
2017 · M.W. Miller, H. Maniates, et al. · Brain Behavior and Immunity · 80
Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease
2017 · Erika J. Wolf, Filomene G. Morrison · Current Psychiatry Reports · 91
The Correlation Of Methylation Levels Measured Using Illumina 450K And EPIC Beadchips In Blood Samples
2017 · Mark W Logue, Alicia K Smith, et al. · Epigenomics · 139
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Accelerated DNA Methylation Age: Associations With Posttraumatic Stress Disorder and Mortality
2017 · Erika J. Wolf, Mark W. Logue, et al. · Psychosomatic Medicine · 77
Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness
2017 · Erika J. Wolf, Danielle R. Miller, et al. · Brain Behavior and Immunity · 31
Posttraumatic stress disorder symptom severity is associated with reduced default mode network connectivity in individuals with elevated genetic risk for psychopathology
2017 · Danielle R. Miller, Mark W. Logue, et al. · Depression and Anxiety · 28
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Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits
2017 · J. A. Sumner, L. E. Duncan, et al. · Psychological Medicine · 31
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