Vascular Growth and Regeneration
Description: NARRATIVE A significant barrier in developing effective therapies to prevent restenosis is our lack of understanding of the cellular and molecular mechanisms controlling endothelial cell regeneration during injury. This application seeks to remove this critical roadblock by bringing information associated to how, where, for how long and under which circumstances endothelial cells are induced to proliferate in the context of a fully functional vessel. Our proposal addresses the exciting possibility that manipulation of specific pathways could reset the entry of endothelial cells into a proliferative state and represent a powerful approach to address vascular repair in humans.
Funding type: research
Funder scheme: R35
Start date: 2018-02-07
End date: 2025-01-31
Investigator: M. LUISA IRUELA-ARISPE
Institution: NORTHWESTERN UNIVERSITY AT CHICAGO
Funded outputs count: 37
Funder award ID: R35HL140014
OpenAlex ID: G778650171