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Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in

Description: PUBLIC HEALTH RELEVANCE: We propose to study the age-dependent macro-molecular damage in yeast. The studies proposed in this application will help elucidate the complex relationship between nutrients, conserved pro- aging signaling pathways, oxidative stress, DNA mutagenesis and protein homeostasis, and mitochondrial function during aging.
Funding type: research
Funder scheme: R01
Start date: 2003-01-01
End date: 2018-05-31
Investigator: VALTER D. LONGO
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Subfield: Aging
Funded outputs count: 75
Funder award ID: R01AG020642
OpenAlex ID: G4896149597
Data from Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index
2023 · Changhan Lee, Fernando M. Safdie, et al.
Fasting and fasting mimicking diets in cancer prevention and therapy
2023 · Olga Blaževitš, Maira Di Tano, et al. · Trends in cancer · 65
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models
2022 · Priya Rangan, Fleur Lobo, et al. · Cell Reports · 69
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Fasting and cancer: from yeast to mammals
2022 · Maira Di Tano, Valter D. Longo · International review of cytology · 5
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
2021 · Giulia Salvadori, Federica Zanardi, et al. · Cell Metabolism · 159
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Intermittent and periodic fasting, longevity and disease
2021 · Valter D. Longo, Maira Di Tano, et al. · Nature Aging · 287
Fasting, dietary restriction, and immunosenescence
2020 · Valter D. Longo, Salvatore Cortellino · Journal of Allergy and Clinical Immunology · 36
A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
2020 · Maira Di Tano, Valter D. Longo · Molecular & Cellular Oncology · 6
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Fasting-mimicking diet and hormone therapy induce breast cancer regression
2020 · Irene Caffa, Vanessa Spagnolo, et al. · Nature · 360
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
2020 · Maira Di Tano, Franca Raucci, et al. · Nature Communications · 153
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Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
2019 · Priya Rangan, Inyoung Choi, et al. · Cell Reports · 312
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Reply to ‘Fasting in oncology: a word of caution’
2019 · Alessio Nencioni, Irene Caffa, et al. · Nature reviews. Cancer · 4
Programmed longevity, youthspan, and juventology
2018 · Valter D. Longo · Aging Cell · 31
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Fasting and cancer: molecular mechanisms and clinical application
2018 · Alessio Nencioni, Irene Caffa, et al. · Nature reviews. Cancer · 518
Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy
2017 · Stefano Di Biase, Hong Seok Shim, et al. · PLoS Biology · 70
Protective effects of short-term dietary restriction in surgical stress and chemotherapy
2017 · Sebastian Brandhorst, Eylul Harputlugil, et al. · Ageing Research Reviews · 64
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
2017 · Min Wei, Sebastian Brandhorst, et al. · Science Translational Medicine · 553
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
2017 · Amy S. Lee, Sebastian Brandhorst, et al. · Scientific Reports · 16
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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
2017 · Chia-Wei Cheng, Valentina Villani, et al. · Cell · 331
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
2016 · Stefano Di Biase, Changhan Lee, et al. · Cancer Cell · 405
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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
2016 · Valter D. Longo, Satchidananda Panda · Cell Metabolism · 1,014
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A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
2016 · In Young Choi, Laura Piccio, et al. · Cell Reports · 507
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Growth factors, aging and age-related diseases
2016 · Priya Balasubramanian, Valter D. Longo · Growth Hormone & IGF Research · 20
Designing a broad-spectrum integrative approach for cancer prevention and treatment
2015 · Keith I. Block, Charlotte Gyllenhaal, et al. · Seminars in Cancer Biology · 300
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The conserved role of protein restriction in aging and disease
2015 · Hamed Mirzaei, Rachel Raynes, et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 54
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