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Molecular mechanisms of translational regulation in aging

Description: Project Narrative The major goal of this grant application is to examine the mechanistic basis of post-transcriptional gene regula- tion in aging using yeast as a model system. For this, we propose to quantitatively analyze transcriptional and translational changes in replicatively aged cells in response to dietary and genetic interventions known to extend lifespan. This information will be integrated to develop a regulatory interaction network and identify factors in- volved in translational regulation of aging genetic pathways.
Funding type: research
Funder scheme: R01
Start date: 2019-04-01
End date: 2026-01-31
Investigator: VYACHESLAV M LABUNSKYY
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Subfield: Aging
Funded outputs count: 19
Funder award ID: R01AG058713
OpenAlex ID: G7313258546
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2026 · Naci Oz, Hetian Su, et al. · eLife
Reviewer #1 (Public review): Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2026 · eLife
Author response: Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2026 · Naci Oz, Hetian Su, et al. · eLife
Reviewer #2 (Public review): Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2026 · eLife
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eLife Assessment: Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2026 · Felix Campelo · eLife
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan
2025 · Naci Oz, Hetian Su, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Disagreement on foundational principles of biological aging
2024 · Vadim N Gladyshev, Benjamin Anderson, et al. · PNAS Nexus · 75
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Lifespan regulation by targeting heme signaling in yeast
2024 · Praveen K. Patnaik, Nour Nady, et al. · GeroScience · 1
Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation
2024 · Hanna Barlit, Antonia M. Romero, et al. · iScience · 9
Regulation of translation in response to iron deficiency in human cells
2024 · Mireia S. Puig-Segui, Carolyn J. Decker, et al. · Scientific Reports · 6
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Manipulating mRNA-binding protein Cth2 function in budding yeast Saccharomyces cerevisiae
2024 · Praveen K. Patnaik, Hanna Barlit, et al. · STAR Protocols
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
2022 · Praveen K. Patnaik, Carine Beaupere, et al. · Cell Reports · 17
Genome-Wide Analysis of Translation in Replicatively Aged Yeast
2021 · Hanna Barlit, Manish K. Rai, et al. · Methods in molecular biology · 2
(Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy
2018 · Carine Beaupere, Vyacheslav M. Labunskyy · Current Genetics · 16
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast
2018 · Carine Beaupere, Leticia Dinatto, et al. · Proceedings of the National Academy of Sciences · 53
Genome-wide Quantification of Translation in Budding Yeast by Ribosome Profiling
2017 · Carine Beaupere, Rosalyn B. Chen, et al. · Journal of Visualized Experiments · 7
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Emerging Omics Approaches in Aging Research
2017 · Jared S. Lorusso, Oleg A. Sviderskiy, et al. · Antioxidants and Redox Signaling · 39
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
2017 · Carine Beaupere, Brian M. Wasko, et al. · Cell Reports · 22
N-terminal acetylation promotes synaptonemal complex assembly in C. elegans
2016 · Jinmin Gao, Consuelo Barroso, et al. · Genes & Development · 41
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