Detrusor Underactivity as an HCN-mediated Failure of Resilience in Aging
Description: Public Relevance The loss of normal voiding ability known as Detrusor Underactivity is a common cause for urinary symptoms including incontinence in later life. Considering DU as a disease of the bladder muscle has yielded no corrective therapy. We propose an innovative approach to Detrusor Underactivity, as the result of exaggerated normal changes of aging contributing to loss of resilience. Using novel methodologies and on-site collaborations possible only within our institution, we will discover specific factors that contribute to a loss of adaptive capabilities in later life which ultimate result in voiding deficiencies characterized by Detrusor Underactivity. These discoveries will re-define evaluative and therapeutic approaches to this difficult disorder.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2019-05-15
End date: 2026-01-31
Investigator: GEORGE A KUCHEL
Institution: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 20
Funder award ID: R01AG058814
OpenAlex ID: G4108680720