The miR-20/c-Myc/E2F Regulatory Axis is Critical for the Tumor Promoting Activity of Inflammatory Fibroblasts in Colitis-Associated Cancer
Description: NARRATIVE The proposed research is relevant to public health because it will seek fundamental knowledge regarding how inflammatory microenvironmental fibroblasts promote oncogenesis through miR-20a and c-Myc. Understanding the pathogenesis of colitis-associated cancer will not only result in preventive strategies for this disease, but also for other inflammation-associated malignancies. Thus, the research is relevant to the part of the NIH’s mission of enhancing health and reducing illness.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2019-03-01
End date: 2025-08-31
Investigator: EMINA HUI-NA HUANG
Institution: UT SOUTHWESTERN MEDICAL CENTER
Funded outputs count: 15
Funder award ID: R01CA237304
OpenAlex ID: G817277655