Regenerate salivary glands via combinatorial pathway intervention
Description: Cancer survivors often endure lifelong dry mouth post radiotherapy, due to ultra-high radiosensitivity and limited regenerative capacity of salivary glands. To address this major clinical challenge, Dr. Gan has developed a murine salivary gland transduction system involving in-utero injection of lentiviral pools containing barcodes and/or gene targeting constructs. This system allows for high fidelity lineage tracing and pathway perturbation and enables the identification of crucial cell populations contributing to salivary gland regeneration post-irradiation. Dr. Gan will functionally dissect the barriers impeding salivary gland regeneration by perturbing differentially regulated molecular pathways post-irradiation. He hypothesizes that the combinatorial removal of several regeneration barriers will lead to comprehensive salivary gland regeneration post-irradiation.
Funding type: fellowship
Funder scheme: The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine
Start date: 2023-01-01
Investigators: Qiwen Gan, Qiwen Gan
Institution: Icahn School of Medicine at Mount Sinai
Funded outputs count: 0
Funder award ID: AACR-2023-qiwen-gan
OpenAlex ID: G9000702237