Age-Related Skeletal Muscle Decline: Integrative Insights from Physiology to Molecular Regulation
Description: This project aims to unravel the mechanisms underlying age-related skeletal muscle dysfunction. Using innovative techniques involving near-infrared spectroscopy (NIRS), as well as advanced microscopy and phosphoproteomics, we will assess mitochondrial function, muscle diffusive capacity, the muscle structures underlying these functions and their molecular regulation in young, middle-aged, and elderly individuals. Additionally, we will investigate the effects of endurance training on mitochondrial function in middle-aged subjects. By understanding how ageing impacts muscle function and exploring exercise interventions, we aim to contribute to both scientific knowledge and potential clinical applications for improving health outcomes in ageing populations.
Funding type: grant
Funder scheme: Open Competitie ENW - M 2023/2024 Pakket 23-4
Start date: 2025-05-01
Investigator: Richie Goulding
Institution: Vrije Universiteit Amsterdam
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: OCENW.M.23.342
OpenAlex ID: G906106670