Analysis of potential stem cells that change their fate from differentiation to self-renewal and support the regeneration of spermatogenesis
Description: Using mouse spermatogenesis, his study investigated the “potential stem cells” that largely differentiate without self-renewal under a normal condition but revert back to self-renewal during regeneration after tissue damage. The discoveries made in this study include: 1) In response to retinoic acid (RA), a differentiation-inducing signal, while GFRα1+ spermatogonia (cells supporting the steady state) remain undifferentiated, while Ngn3+ cells (those acting as potential stem cells) undergo irreversible differentiation and lose the stem cell potential. 2) This differential RA responsiveness is caused by the differential expression of RARg (a RA receptor gene) only in the Ngn3+ cells. These findings suggest a novel regulatory mechanism for the robust stem cell systems.
Amount: ¥45,890,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (A)
Start date: 2012-05-31
End date: 2016-03-31
Investigator: Shosei YOSHIDA
Institution: National Institute for Basic Biology
Funded outputs count: 8
Funder award ID: 24247041
OpenAlex ID: G913971569