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PPARgamma Deacetylation in the Restoration of Metabolic Homeostasis

Description: This project addresses a major unmet clinical need by investigating a mechanism to activate nuclear receptor PPARγ and leverage its insulin-sensitizing properties for the treatment of insulin resistance and diabetes, while preventing the adverse effects of PPARγ agonists on the body weight, cardiovascular system, bone, and fluid balance.
Funding type: research
Funder scheme: R01
Start date: 2017-12-01
End date: 2022-11-30
Investigator: LI QIANG
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Funded outputs count: 21
Funder award ID: R01DK112943
OpenAlex ID: G4157717153
Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety
2025 · Dan Wu, Zhen Gong, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
2024 · Lexiang Yu, Qianfen Wan, et al. · Cell Metabolism · 119
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A glimpse of the connection between PPARγ and macrophage
2023 · Lexiang Yu, Yuen Gao, et al. · Frontiers in Pharmacology · 54
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Deciphering the decline of metabolic elasticity in aging and obesity
2023 · Qiuzhong Zhou, Lexiang Yu, et al. · Cell Metabolism · 80
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction
2023 · Ying He, Ruotong Zhang, et al. · Cells · 24
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Uncoupling Lipid Synthesis from Adipocyte Development
2023 · Qianfen Wan, Carmen Calhoun, et al. · Biomedicines · 10
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PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia
2022 · Tarik Zahr, Longhua Liu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 26
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PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
2022 · Ying He, Alana B'nai Taub, et al. · Advanced Science · 40
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Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity
2022 · Nicole Aaron, Tarik Zahr, et al. · Life Metabolism · 17
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Adipokines, adiposity, and atherosclerosis
2022 · Longhua Liu, Zunhan Shi, et al. · Cellular and Molecular Life Sciences · 176
The Implications of Bone Marrow Adipose Tissue on Inflammaging
2022 · Nicole Aaron, Samantha Costa, et al. · Frontiers in Endocrinology · 74
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Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
2021 · Nicole Aaron, Michael J Kraakman, et al. · eLife · 70
Adipsin deficiency does not impact atherosclerosis development in Ldlr −/− mice
2020 · Longhua Liu, Michelle Chan, et al. · American Journal of Physiology-Endocrinology and Metabolism · 16
Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis
2020 · Lauren R. Richter, Qianfen Wan, et al. · ACS Nano · 59
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
2020 · Longhua Liu, Lihong Fan, et al. · Diabetes · 29
A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging
2020 · Qiuzhong Zhou, Qianfen Wan, et al. · Cell Reports · 51
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Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity
2020 · Kristin M. McCabe, Joanne Hsieh, et al. · Molecular Metabolism · 18
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Identification of a natural beige adipose depot in mice
2019 · Michelle Chan, Yen Ching Lim, et al. · Journal of Biological Chemistry · 24
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The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity
2018 · Maria Namwanje, Longhua Liu, et al. · Journal of Endocrinology · 25
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PPARγ deacetylation dissociates thiazolidinedione’s metabolic benefits from its adverse effects
2018 · Michael J. Kraakman, Qiongming Liu, et al. · Journal of Clinical Investigation · 60
Guided delivery of polymer therapeutics using plasmonic photothermal therapy
2012 · Adam J. Gormley, Nate Larson, et al. · Nano Today · 119
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