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20H05927

Funded outputs count: 31
Funder award ID: 20H05927
OpenAlex ID: G93105122
Non-coding repeat analyses in patients with Parkinson’s disease
2025 · Makito Hirano, Makoto Samukawa, et al. · Frontiers in Neurology · 1
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Dissecting the mechanism of NOP56 GGCCUG repeat-associated non-AUG translation using cell-free translation systems
2025 · Mayuka Hasumi, Hayato Ito, et al. · Journal of Biological Chemistry · 6
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TDP-43 transports ferritin heavy chain mRNA to regulate oxidative stress in neuronal axons
2025 · Jyunki Jinno, Rehab F. Abdelhamid, et al. · Neurochemistry International · 8
Alternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA‐Binding Protein 43 kDa Functions
2025 · Takashi Miwa, Eriko Takeuchi, et al. · Neurology and Clinical Neuroscience · 2
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Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
2024 · Tetsuhiro Ueda, Toshihide Takeuchi, et al. · Acta Neuropathologica Communications · 14
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eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS
2024 · Shiho Gotoh, Kohji Mori, et al. · Journal of Biological Chemistry · 12
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Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles
2023 · Keita Kakuda, Kensuke Ikenaka, et al. · Proceedings of the National Academy of Sciences · 65
Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors
2023 · Hayato Ito, Kodai Machida, et al. · Scientific Reports · 9
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CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy
2023 · Makito Hirano, Motoi Kuwahara, et al. · Scientific Reports · 7
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Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism
2023 · Chi-Jing Choong, César Aguirre, et al. · Acta Neuropathologica · 30
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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
2023 · Yuzo Fujino, Morio Ueyama, et al. · eLife · 20
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Repeat-associated non-AUG translation in neuromuscular diseases: mechanisms and therapeutic insights
2023 · Yuzo Fujino, Kohji Mori, et al. · The Journal of Biochemistry · 9
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What repeat expansion disorders can teach us about the Central Dogma
2023 · Eric T. Wang, Catherine H. Freudenreich, et al. · Molecular Cell · 3
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Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice
2023 · Toshihide Takeuchi, Kazuhiro Maeta, et al. · Molecular Therapy — Nucleic Acids · 33
Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA
2023 · Yohei Nitta, Hiroki Kawai, et al. · Human Molecular Genetics · 13
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Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72 -linked ALS/FTD
2022 · Tomoya Taminato, Toshihide Takeuchi, et al. · Human Molecular Genetics · 14
Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics
2022 · Toshihide Takeuchi, Yoshitaka Nagai · Neurochemistry International · 11
The molecular pathogenesis of repeat expansion diseases
2021 · Yuzo Fujino, Yoshitaka Nagai · Biochemical Society Transactions · 20
ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid–liquid phase separation and liquid-to-solid transition
2021 · Akira Ishiguro, Jun Lu, et al. · Journal of Biological Chemistry · 64
The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene
2021 · Kohji Mori, Shiho Gotoh, et al. · Journal of Biological Chemistry · 23
Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
2021 · Seiya Oura, Taichi Noda, et al. · Communications Biology · 35
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Insight Into Spinocerebellar Ataxia Type 31 (SCA31) From Drosophila Model
2021 · Taro Ishiguro, Yoshitaka Nagai, et al. · Frontiers in Neuroscience · 17
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Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold
2021 · Rubén Hervás, María del Carmen Fernández-Ramírez, et al. · BMC Biology · 32
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Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases
2021 · Eiko N. Minakawa, Yoshitaka Nagai · Frontiers in Neuroscience · 49
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Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
2021 · Tomonori Shibata, Konami Nagano, et al. · Nature Communications · 61
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