Development of rehabilitation for skeletal muscle aging focusing on basement menbrane construction by fibroblasts
Description: In the present study, it was found that (1) intramuscular fibroblasts play an important role in the reconstruction of the basement membrane, (2) aging decreases basement membrane related factors not only during muscle recovery but also from the steady state, and (3) endurance exercise activates basement membrane related factors in aging. These results suggest that exercise intervention may stimulate the production of collagen IV by fibroblasts and improve the basement membrane construction ability in aged skeletal muscle.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Yuji Kanazawa
Institution: Osaka University of Human Sciences
Funded outputs count: 2
Funder award ID: 18K17776
OpenAlex ID: G932216779