The exploration of novel genes for elastogenesis and application to regeneration of elastic fibers
Description: We analyzed the genes that altered by the qualitative and quantitative modification of elastic fiber in fibroblasts, resulting in we obtained 16 fluctuated genes. We focused on the genes related to Wnt signaling, which is essential for development during the embryonic period, from the 16 genes. DKK2, an intrinsic inhibitor of Wnt, was reduced the formation of elastic and microfibril fibers without decreasing the expression of constituent molecules. These results suggest that a novel factor promoting elastic fiber formation is induced through the Wnt signal.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: FUMIAKI SATO
Institution: Hoshi University
Funded outputs count: 0
Funder award ID: 18K08280
OpenAlex ID: G932428209