Interactions between androgen action and diet-induced metabolic disorders
Description: The effects of dietary composition on metabolic disorders induced by androgen action deficiencies were studied using rodent models.(1) Male androgen receptor knockout mice exhibited obesity, glucose intolerance, and a reduced lifespan when fed a high-fat diet. The observed metabolic disorders were attributed to gut microbiota.(2) Inhibition of fetal androgen action suppressed pancreatic β-cell development in male rats. The rats exhibited insulin defects and glucose intolerance when fed high-fat diets.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Naoki Harada
Institution: Osaka Prefecture University
Funded outputs count: 8
Funder award ID: 16K07743
OpenAlex ID: G951066829