Elucidating the cardiomyocytes damage caused by Toxic Advanced Glycation End-products (TAGE) and the underlying mechanism
Description: The reduced beating rate and the cell viability were dependent on Toxic Advanced Glycation End-Products (Toxic AGEs, TAGE) production/accumulation after the addition of glyceraldehyde (GA), a precursor of TAGE, to the culture of rat primary cardiomyocytes. Additionally, autophagy may be inhibited in cells with TAGE production/accumulation. In addition, extracellular TAGE, such as blood TAGE, did not cause apoptosis in cardiomyocytes at a physiological concentration.Also, the effects of high glucose and fructose levels on cardiomyocytes were examined in relation to TAGE.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Takanobu TAKATA
Institution: Kanazawa Medical University
Subfield: Clinical Biochemistry
Domain: Life Sciences
Funded outputs count: 8
Funder award ID: 18K11139
OpenAlex ID: G953105227