Regulation of transcriptional consistency by broad H3K4me3 domains in young cells and during aging
Description: PUBLIC HEALTH RELEVANCE: Understanding how complex regulatory processes deteriorate during aging should help delay age-related diseases. Transcriptional precision is an important aspect of gene expression regulation, which affects how cells respond to environmental fluctuations and becomes misregulated during aging. This study aims at understanding the mechanisms underlying transcriptional variability in young cells and during aging and should ultimately provide a molecular handle to rejuvenate dysfunctional aged cells to a youthful healthy functional state, which should have key implications for delaying age-related diseases.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K99
Start date: 2015-04-15
End date: 2017-07-14
Investigator: BERENICE ANATH BENAYOUN
Institution: STANFORD UNIVERSITY
Funded outputs count: 7
Funder award ID: K99AG049934
OpenAlex ID: G1723917051