Loss of progenitor function accelerates lung aging
Description: Aging is associated with loss of lung structure, declining function, and increased susceptibility to lung disease, together termed senile emphysema. The goal of this proposal is to define mechanisms that result in loss of adult mesenchymal vascular progenitor and innate lymphoid progenitor cell function, contributing to accelerated lung aging and increased susceptibility to emphysema in the aged population.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-06-15
End date: 2028-02-29
Investigator: SUSAN M MAJKA
Institution: NATIONAL JEWISH HEALTH
Funded outputs count: 14
Funder award ID: R01AG073317
OpenAlex ID: G9000859026