Nuclear-Mitochondrial Fitness Interactions in Drosophila
Description: PROJECT NARRATIVE Mitochondrial dysfunction is a leading cause of metabolic disease, affecting 1 in ~5000 individuals and this high incidence of disease is likely due to the complex genomic basis of mitochondrial function, which requires coordinated expression of 37 genes in the mitochondrial genome (mtDNA) and more than 1000 genes in the nuclear genome. This project will dissect the joint contribution of mtDNA- and nuclear-encoded genes to developmental delay in Drosophila and determine how dietary modifications can rescue or exacerbate this delay. These experiments will provide information about the genetic basis of mitochondrial function for pathways related to obesity and metabolic syndromes, and may contribute to our understanding of the genetics of mitochondrial replacement therapy and the development of pharmaceuticals that compensate for reduced mitochondrial function.
Funding type: research
Funder scheme: R01
Start date: 2004-08-01
End date: 2022-03-31
Investigator: DAVID M RAND
Institution: BROWN UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 69
Funder award ID: R01GM067862
OpenAlex ID: G3404670308