Using mouse models to dissect the roles of ZMPSTE24 and prelamin A in accelerated aging
Description: PROJECT NARRATIVE Prelamin A is protein that is processed by an enzyme called ZMPSTE24 into to lamin A, a structural component of the cell nucleus. Alterations in prelamin A and ZMPSTE24 have been implicated in accelerated aging syndromes and possibly normal aging. This project will dissect their roles in accelerated aging.
Funder: National Institutes of Health
Amount: $82,250
Funding type: research
Funder scheme: R03
Start date: 2024-07-01
End date: 2026-06-30
Investigator: HOWARD J WORMAN
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 1r03ag088752-01
OpenAlex ID: G967869799