Nucleotide Metabolism in Senescence and Platinum Resistance of Ovarian Cancer
Description: PUBLIC HEALTH RELEVANCE: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy in the US. Current treatments for EOC are ineffective as the vast majority of women will have recurrent disease. Therefore, there is an urgent need to develop new ways to treat EOC patients. In this study, I will determine whether nucleotide metabolism, which leads to synthesis of the building blocks of DNA, plays a role in the early events in cancer. I will also evaluate inhibition of nucleotide metabolism in combination with current standard-of-care treatment. The results will have a direct impact on the development of novel therapeutic strategies to obtain a sustained therapeutic response.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R00
Start date: 2017-01-25
End date: 2020-08-31
Investigator: KATHERINE MARIE AIRD
Institution: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
Funded outputs count: 22
Funder award ID: R00CA194309
OpenAlex ID: G6203272202