Immunosenescence, socioeconomic disadvantage and dementia in the US aging population
Description: Project Narrative Many questions remain regarding the role of immunity in the etiology of cognitive decline and Alzheimer's Disease and related dementias (ADRD). Using the Health and Retirement Study (HRS), we will examine associations between peripheral immunosenescence and cognitive function, decline, and incident ADRD, with specific attention to social inequalities in these processes. At its conclusion, this study will yield critical insights to our understanding of the pathophysiology of cognitive decline and ADRD, creating new opportunities for early detection and targeting at the population level.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2022-03-01
End date: 2026-11-30
Investigator: ALLISON E AIELLO
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Funded outputs count: 19
Funder award ID: R01AG075719
OpenAlex ID: G9000910396