Get started
Award

Regulation of Peripheral Proteostasis

Description: PROJECT NARRATIVE Among the most daunting diseases are those known as protein conformational diseases that cause neurodegeneration including Alzheimer's disease, Parkinson's disease, ALS and Huntington's disease. Each of these diseases and hundreds of others are due to protein aggregation and resulting tissue failure. This proposal is to address how different tissues communicate and coordinate the cellular response to aggregation and proteotoxicity.
Funding type: research
Funder scheme: RF1
Start date: 2017-09-15
End date: 2022-08-31
Investigator: RICHARD I MORIMOTO
Institution: NORTHWESTERN UNIVERSITY
Funded outputs count: 25
Funder award ID: RF1AG057296
OpenAlex ID: G1107271504
Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues
2024 · Ambre J. Sala, Rogan A. Grant, et al. · Genes & Development · 4
A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway
2023 · Overall coordination, Suzanne Elsasser, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 24
PDF
Aging is associated with a systemic length-associated transcriptome imbalance
2022 · Thomas Stoeger, Rogan A. Grant, et al. · Nature Aging · 121
PDF
Protecting the future: balancing proteostasis for reproduction
2021 · Ambre J. Sala, Richard I. Morimoto · Trends in Cell Biology · 41
Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy
2021 · Laura C Bott, Mitra Forouhan, et al. · Brain Communications · 34
Autophagy in healthy aging and disease
2021 · Yahyah Aman, Tomas Schmauck-Medina, et al. · Nature Aging · 1,314
PDF
The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3‐4, 2021
2021 · Chen Lior, Francesca Hodge, et al. · The FASEB Journal · 1
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
2021 · Satoshi Watanabe, Nikolay S. Markov, et al. · Proceedings of the National Academy of Sciences · 97
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
2021 · Tessa Sinnige, Georg Meisl, et al. · Proceedings of the National Academy of Sciences · 23
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging
2021 · Alexandra C. McQuattie-Pimentel, Ziyou Ren, et al. · Journal of Clinical Investigation · 177
PDF
Recapitulation of Endogenous 4R Tau Expression and Formation of Insoluble Tau in Directly Reprogrammed Human Neurons
2021 · Lucia S. Capano, Chihiro Sato, et al. · Cell stem cell · 65
PDF
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
2020 · Tessa Sinnige, Georg Meisl, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
PDF
ERdj8 governs the size of autophagosomes during the formation process
2020 · Yo-hei Yamamoto, Ayano Kasai, et al. · The Journal of Cell Biology · 34
Embryo integrity regulates maternal proteostasis and stress resilience
2020 · Ambre J. Sala, Laura C. Bott, et al. · Genes & Development · 31
PDF
Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease
2020 · Tessa Sinnige, Anan Yu, et al. · Advances in experimental medicine and biology · 67
A metastable subproteome underlies inclusion formation in muscle proteinopathies
2019 · Prajwal Ciryam, Matthew Antalek, et al. · Acta Neuropathologica Communications · 22
PDF
Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease
2019 · Richard I. Morimoto · Cold Spring Harbor Perspectives in Biology · 98
PDF
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
2019 · Anan Yu, Susan G. Fox, et al. · Journal of Biological Chemistry · 55
PDF
Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing
2019 · Julia M. D. Grandjean, Lars Plate, et al. · ACS Chemical Biology · 73
PDF
Large-scale investigation of the reasons why potentially important genes are ignored
2018 · Thomas Stoeger, Martin Gerlach, et al. · PLoS Biology · 262
PDF
Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging
2017 · Johnathan Labbadia, Renee M. Brielmann, et al. · Cell Reports · 165
In vivo properties of the disaggregase function of J‐proteins and Hsc70 in Caenorhabditis elegans stress and aging
2017 · Janine Kirstein, Kristin Arnsburg, et al. · Aging Cell · 54
PDF
Long-range correlations and fractal dynamics inC. elegans: Changes with aging and stress
2017 · Luiz G. A. Alves, Peter B. Winter, et al. · Physical review. E · 19
Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease
2017 · Rishika Kundra, Prajwal Ciryam, et al. · Proceedings of the National Academy of Sciences · 92
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
2017 · Prajwal Ciryam, Isabella A. Lambert-Smith, et al. · Proceedings of the National Academy of Sciences · 101
PDF
Year
Topic