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Sygnature Discovery (Canada)

Alternate names: NuChem Sciences Inc., Sygnature Discovery
ROR: 04s38rg66
OpenAlex ID: I4405263679
RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
2021 · Anne Roulston, Michal Zimmermann, et al. · Molecular Cancer Therapeutics · 93
Calix[n]arenes and its derivatives as organocatalysts
2022 · Garima Sachdeva, Dipti Vaya, et al. · Coordination Chemistry Reviews · 69
Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models
2020 · Ahmed A. Ahmed, Richard Angell, et al. · ACS Medicinal Chemistry Letters · 58
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I
2021 · Shashi Jain, Cheng Hu, et al. · Cell chemical biology · 48
Photoredox Activation of Anhydrides for the Solvent‐Controlled Switchable Synthesis of gem ‐Difluoro Compounds**
2022 · Rahul Giri, Ivan Mosiagin, et al. · Angewandte Chemie International Edition · 44
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Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids
2021 · Yang Zhang, Yunpeng Ji, et al. · Angewandte Chemie International Edition · 40
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)
2024 · W. Cameron Black, Abbas Abdoli, et al. · Journal of Medicinal Chemistry · 37
Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
2022 · Yunpeng Ji, Benke Hong, et al. · Angewandte Chemie International Edition · 32
Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders
2024 · Corentin Bouvier, Rachel Lawrence, et al. · Cells · 29
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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model
2020 · Christophe Fromont, Alessio Atzori, et al. · Journal of Medicinal Chemistry · 27
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EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells
2023 · Narjara Gonzalez Suarez, Yuniel Fernandez-Marrero, et al. · Cancer Cell International · 26
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Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling
2023 · Sahily Rodriguez Torres, Loraine Gresseau, et al. · Biomedicines · 26
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Dearomative Cyclopropanation of Naphthols via Cyclopropene Ring‐Opening
2021 · Rachel J. Baker, Justin Ching, et al. · Angewandte Chemie International Edition · 25
Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia
2019 · Xingjian Li, Daniel T. Payne, et al. · MedChemComm · 24
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Facile access to a heterocyclic, sp 3 -rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy
2015 · M. J. Rawling, T. E. Storr, et al. · Chemical Communications · 23
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Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor
2025 · Frédéric Vallée, Matias Casás-Selves, et al. · Journal of Medicinal Chemistry · 15
Synthesis of a Zirconium Complex of an N , O -type p - tert -Butylcalix[4]arene and Its Application in Some Multicomponent Reactions
2022 · Varun Rawat, Arkadi Vigalok, et al. · ACS Omega · 14
Predicting protein–ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A
2019 · Iva Lukac, Hend Abdelhakim, et al. · Chemical Science · 14
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JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model1
2022 · Jessica L. Dennison, Claude-Henry Volmar, et al. · Journal of Alzheimer s Disease · 13
Design and Synthesis of Novel β‐Carboline‐Bisindole Hybrids as Potential Anticancer Agents
2024 · Nguyen Thi Thanh Huyen, Ban Van Phuc, et al. · ChemMedChem · 9
Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids
2021 · Yang Zhang, Yunpeng Ji, et al. · Angewandte Chemie · 8
Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities
2018 · Euan A. F. Fordyce, S. Fraser Hunt, et al. · MedChemComm · 8
Mechanisms that matter: unbiased cellular screening for degraders
2025 · Helen E. Burston, Elizabeth M. Rosethorne, et al. · npj Drug Discovery. · 7
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Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
2022 · Yunpeng Ji, Benke Hong, et al. · Angewandte Chemie · 6
Dearomative Cyclopropanation of Naphthols via Cyclopropene Ring‐Opening
2021 · Rachel J. Baker, Justin Ching, et al. · Angewandte Chemie · 6
Works count: 61
Citation count: 2,004
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