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Axcelead Drug Discovery Partners Inc. (Japan)
Homepage:
axcelead-hd.com
Alternate names:
Axcelead Drug Discovery Partners,
Axcelead Drug Discovery Partners Inc.,
Axcelead Drug Discovery Partners株式会社
ROR:
01gy5eb25
OpenAlex ID:
I4405264295
Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole
2021
·
Tatsuki Asai
, Naruhiko Adachi
, et al.
·
Structure
·
99
Identification of the first highly selective inhibitor of human lactate dehydrogenase B
2021
·
Sachio Shibata
, Satoshi Sogabe
, et al.
·
Scientific Reports
·
71
PDF
A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice
2021
·
Tomohiro Onishi
, Ryouta Maeda
, et al.
·
Scientific Reports
·
61
PDF
Ngly1 −/− rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems
2020
·
Makoto Asahina
, Reiko Fujinawa
, et al.
·
Human Molecular Genetics
·
55
PDF
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
2018
·
Norihito Shibata
, Kenichiro Shimokawa
, et al.
·
Scientific Reports
·
52
PDF
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog
2021
·
Jochen Woicke
, Muthafar M. Al-Haddawi
, et al.
·
Toxicologic Pathology
·
47
Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
2022
·
Toshiki Kurosawa
, Daiki Sako
, et al.
·
Pharmaceutical Research
·
41
PDF
ReDSHIFT: A Global Approach to Space Debris Mitigation
2018
·
Alessandro Rossi
, Camilla Colombo
, et al.
·
Aerospace
·
39
PDF
Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis
2020
·
Mitsuharu Matsumoto
, Hiroaki Yashiro
, et al.
·
PLoS ONE
·
37
PDF
Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression
2020
·
Vasiliki Papadaki
, Ken Asada
, et al.
·
Cancers
·
34
A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
2021
·
Kenichi Iwai
, Tadahiro Nambu
, et al.
·
Science Advances
·
32
Prediction of ligand binding mode among multiple cross-docking poses by molecular dynamics simulations
2020
·
Kai Liu
, Hironori Kokubo
·
Journal of Computer-Aided Molecular Design
·
32
Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop
2018
·
B. Lenz
, A. Braendli-Baiocco
, et al.
·
Toxicologic Pathology
·
32
PDF
Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells
2023
·
Marenori Kojima
, Katsuya Suzuki
, et al.
·
Communications Biology
·
31
PDF
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens
2021
·
Yukie Kashima
, Yosuke Togashi
, et al.
·
Scientific Reports
·
30
PDF
Biodistribution studies for cell therapy products: Current status and issues
2021
·
Yoshiteru Kamiyama
, Yoichi Naritomi
, et al.
·
Regenerative Therapy
·
29
PDF
JF1/B6F1 Ngly1−/− mouse as an isogenic animal model of NGLY1 deficiency
2021
·
Makoto ASAHINA
, Reiko FUJINAWA
, et al.
·
Proceedings of the Japan Academy Series B
·
29
PDF
Artificial intelligence in drug discovery — what it is, where we stand and the path forward
2026
·
Andreas Bender
, Morgan C. Thomas
, et al.
·
Nature Reviews Drug Discovery
·
28
Differentiation-associated apoptosis of neural stem cells is effected by Bcl-2 overexpression: impact on cell lineage determination
2001
·
Christina Esdar
, Sandra Milasta
, et al.
·
European Journal of Cell Biology
·
24
Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein–protein interaction-oriented library and machine learning
2021
·
Yugo Shimizu
, Tomoki Yonezawa
, et al.
·
Scientific Reports
·
22
PDF
Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies
2021
·
Justin D. Vidal
, Karyn Colman
, et al.
·
Toxicologic Pathology
·
22
Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC
2022
·
Hideyuki Hiyoshi
, Kensuke Sakuma
, et al.
·
Scientific Reports
·
21
PDF
A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease
2021
·
Takahiro Fujii
, Yuta Tanaka
, et al.
·
Journal of Neurochemistry
·
21
PDF
Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives
2017
·
Mitsunori Kono
, Tsuneo Oda
, et al.
·
Bioorganic & Medicinal Chemistry
·
21
Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
2018
·
Yoshiki Nakamura
, Keiko Igaki
, et al.
·
Inflammation Research
·
20
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Works count:
111
Citation count:
3,362
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