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Fuji Yakuhin Co., Ltd. (Japan)
Homepage:
fujiyakuhin.co.jp
Alternate names:
Fuji Yakuhin,
Fuji Yakuhin Co., Ltd.,
Fujiyakuhin Co., Ltd.
ROR:
0031t6k06
OpenAlex ID:
I4405266857
The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition
2004
·
Ken Okamoto
, Koji Matsumoto
, et al.
·
Proceedings of the National Academy of Sciences
·
290
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
1999
·
N Kondoh
, T Wakatsuki
, et al.
·
PubMed
·
232
Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action
2000
·
Hiroyuki Nakano
, Tsutomu Inoue
, et al.
·
Bioorganic & Medicinal Chemistry
·
215
Enhanced expression of translation factor mRNAs in hepatocellular carcinoma.
2000
·
M Shuda
, N Kondoh
, et al.
·
PubMed
·
133
Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor
2019
·
Tetsuya Taniguchi
, Naoki Ashizawa
, et al.
·
Journal of Pharmacology and Experimental Therapeutics
·
108
PDF
Effects of topiroxostat and febuxostat on urinary albumin excretion and plasma xanthine oxidoreductase activity in db/db mice
2016
·
Takashi Nakamura
, Takayo Murase
, et al.
·
European Journal of Pharmacology
·
82
Synthesis of Benzimidazole Derivatives as Antiallergic Agents with 5-Lipoxygenase Inhibiting Action.
1999
·
Hiroyuki NAKANO
, Tsutomu INOUE
, et al.
·
Chemical and Pharmaceutical Bulletin
·
68
PDF
Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double‐blind, double‐dummy, active‐controlled, parallel‐group study
2016
·
T. Hosoya
, Y. Ogawa
, et al.
·
Journal of Clinical Pharmacy and Therapeutics
·
62
PDF
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study)
2018
·
Takashi Wada
, Tatsuo Hosoya
, et al.
·
Clinical and Experimental Nephrology
·
61
PDF
Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study
2020
·
Tatsuo Hosoya
, Takafumi Sano
, et al.
·
Clinical and Experimental Nephrology
·
59
PDF
Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout
2021
·
Tomohiko Ishikawa
, Toshinari Takahashi
, et al.
·
Expert Opinion on Pharmacotherapy
·
56
PDF
Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2
2021
·
Tetsuya Taniguchi
, Koichi Omura
, et al.
·
Scientific Reports
·
53
PDF
Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study
2016
·
Tatsuo Hosoya
, Tomomitsu Sasaki
, et al.
·
Clinical Rheumatology
·
52
PDF
Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia
2009
·
Takahiro Sato
, Naoki Ashizawa
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
48
Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity
2020
·
Junichiro Uda
, Seiichi Kobashi
, et al.
·
ACS Medicinal Chemistry Letters
·
47
Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double‐blind, placebo‐controlled study
2016
·
T. Hosoya
, T. Sasaki
, et al.
·
Journal of Clinical Pharmacy and Therapeutics
·
47
Direct Z-scheme covalent triazine-based framework/Bi2WO6 heterostructure for efficient photocatalytic degradation of tetracycline: Kinetics, mechanism and toxicity
2022
·
Shiyun Deng
, Zhenzhen Li
, et al.
·
Journal of Water Process Engineering
·
42
Open-label study of long-term administration of dotinurad in Japanese hyperuricemic patients with or without gout
2019
·
Tatsuo Hosoya
, Masahiko Fushimi
, et al.
·
Clinical and Experimental Nephrology
·
39
PDF
Xanthine oxidoreductase activity assay in tissues using stable isotope-labeled substrate and liquid chromatography high-resolution mass spectrometry
2015
·
Takayo Murase
, Mai Nampei
, et al.
·
Journal of Chromatography B
·
37
Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors
2008
·
Takahiro Sato
, Naoki Ashizawa
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
37
Long-Term Safety and Effectiveness of the Xanthine Oxidoreductase Inhibitor, Topiroxostat in Japanese Hyperuricemic Patients with or Without Gout: A 54-week Open-label, Multicenter, Post-marketing Observational Study
2020
·
Tomohiko Ishikawa
, Tatsushi Maeda
, et al.
·
Clinical Drug Investigation
·
36
PDF
Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study
2019
·
Tatsuo Hosoya
, Takafumi Sano
, et al.
·
Clinical and Experimental Nephrology
·
33
PDF
Comparison on Thermal Runaway and Critical Characteristics of Cylindrical Lithium-Ion Batteries: A Review
2025
·
Wei Li
, Jiasheng Wang
, et al.
·
ACS Chemical Health & Safety
·
28
A Synthesis of d , l -N,N-Dimethylcycloisodityrosines: A Comment on the Stereochemistry of Previously Reported Intermediates Related to the Synthesis of RA-VII and Deoxybouvardin
1996
·
Tsutomu Inoue
, Tomomitsu Sasaki
, et al.
·
The Journal of Organic Chemistry
·
27
Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice
2021
·
Takuji Hosoya
, Shunya Uchida
, et al.
·
Journal of the American Society of Nephrology
·
26
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Works count:
137
Citation count:
8,449
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