Galera Therapeutics, Inc. (United States)

Alternate names: Galera Therapeutics, Galera Therapeutics, Inc.

ROR: 00g2rvr59

OpenAlex ID: I4405266955

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

2017 · Joshua D. Schoenfeld, Zita A. Sibenaller, et al. · Cancer Cell · 457

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Antioxidants in Translational Medicine

2015 · Harald H.H.W. Schmidt, Roland Stocker, et al. · Antioxidants and Redox Signaling · 233

Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer

2019 · Carryn M. Anderson, Christopher M. Lee, et al. · Journal of Clinical Oncology · 130

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

2018 · Kranti A. Mapuskar, Hsiang Wen, et al. · Redox Biology · 115

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Phase 1b/2a Trial of the Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-Induced Oral Mucositis in Patients With Oral Cavity or Oropharyngeal Carcinoma

2017 · Carryn M. Anderson, Stephen T. Sonis, et al. · International Journal of Radiation Oncology*Biology*Physics · 82

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma

2015 · Brianne R. O'Leary, Melissa A. Fath, et al. · Clinical Cancer Research · 72

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury

2021 · Kranti A. Mapuskar, Emily J. Steinbach, et al. · Antioxidants · 64

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Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

2021 · Brock J. Sishc, Lianghao Ding, et al. · Science Translational Medicine · 53

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

2018 · Collin Heer, Andrew Davis, et al. · Antioxidants · 52

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Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy

2017 · Kranti A. Mapuskar, Kyle H. Flippo, et al. · Cancer Research · 43

Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3

2013 · Mitchell C. Coleman, Alicia K. Olivier, et al. · Antioxidants and Redox Signaling · 41

Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial

2023 · Cullen M Taniguchi, Jessica M Frakes, et al. · The Lancet Oncology · 38

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The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury

2024 · Kranti A. Mapuskar, Casey F. Pulliam, et al. · Redox Biology · 33

Two-Year Tumor Outcomes of a Phase 2B, Randomized, Double-Blind Trial of Avasopasem Manganese (GC4419) Versus Placebo to Reduce Severe Oral Mucositis Owing to Concurrent Radiation Therapy and Cisplatin for Head and Neck Cancer

2022 · Carryn M. Anderson, Christopher M. Lee, et al. · International Journal of Radiation Oncology*Biology*Physics · 22

Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

2023 · K.A. Mapuskar, G. Vasquez Martinez, et al. · Redox Biology · 21

ROMAN: Phase 3 trial of avasopasem manganese (GC4419) for severe oral mucositis (SOM) in patients receiving chemoradiotherapy (CRT) for locally advanced, nonmetastatic head and neck cancer (LAHNC).

2022 · Carryn M. Anderson, Christopher M. Lee, et al. · Journal of Clinical Oncology · 20

Randomized, Double-Blinded, Placebo-controlled Multicenter Adaptive Phase 1-2 Trial of GC 4419, a Dismutase Mimetic, in Combination with High Dose Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (PC)

2020 · S. Hoffe, J.M. Frakes, et al. · International Journal of Radiation Oncology*Biology*Physics · 18

Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence

2025 · Sung-Jen Wei, Joseph Schell, et al. · Cell Reports · 16

Benefit of Avasopasem Manganese on Severe Oral Mucositis in Head and Neck Cancer in the ROMAN Trial: Unplanned Secondary Analysis

2024 · Carryn Anderson, Samuel Salvaggio, et al. · Advances in Radiation Oncology · 11

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Tumor Outcomes for ROMAN: Phase 3 Trial of Avasopasem Manganese (GC4419) for Severe Oral Mucositis (SOM) in Patients Receiving Chemoradiotherapy (CRT) for Locally Advanced Head and Neck Cancer (LAHNC)

2022 · C.M. Anderson, C.M. Lee, et al. · International Journal of Radiation Oncology*Biology*Physics · 11

Avasopasem manganese treatment for severe oral mucositis from chemoradiotherapy for locally advanced head and neck cancer: phase 3 randomized controlled trial (ROMAN)

2025 · Carryn Anderson, Christopher M. Lee, et al. · EClinicalMedicine · 9

Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2

2025 · C.F. Pulliam, M.A. Fath, et al. · Redox Biology · 8

The impact of isolated local recurrence on long-term outcome in early-breast cancer patients after breast-conserving therapy

2021 · Conny Vrieling, Samson Y. Assele, et al. · European Journal of Cancer · 8

Phase 1b/2a Trial of Superoxide (SO) Dismutase (SOD) Mimetic GC4419 to Reduce Chemoradiation Therapy–Induced Oral Mucositis (OM) in Patients With Oral Cavity or Oropharyngeal Carcinoma (OCC)

2016 · C.M. Anderson, B.G. Allen, et al. · International Journal of Radiation Oncology*Biology*Physics · 7

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Stereotactic Body Radiotherapy Plus Rucosopasem in Locally Advanced or Borderline Resectable Pancreatic Cancer: GRECO-2 Phase II Study Design

2024 · Sarah E Hoffe, Todd A Aguilera, et al. · Future Oncology · 6

Works count: 66

Citation count: 2,546