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Vigonvita Life Sciences Co., Ltd. (China)
Homepage:
vigonvita.cn
Alternate names:
Suzhou Wangshan Wangshui Bio-Pharmaceutical Co., Ltd.,
Vigonvita Life Sciences,
Vigonvita Life Sciences Co., Ltd.
ROR:
055wcyn58
OpenAlex ID:
I4405267959
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
2021
·
Yuanchao Xie
, Wanchao Yin
, et al.
·
Cell Research
·
140
PDF
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
2022
·
Hong-jie Qian
, Yu Wang
, et al.
·
Acta Pharmacologica Sinica
·
78
PDF
Pharmacokinetics-Driven Optimization of 4(3 H )-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
2019
·
Zhen Wang
, Xiangrui Jiang
, et al.
·
Journal of Medicinal Chemistry
·
46
Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability
2025
·
Fengying Wu
, Qing Ma
, et al.
·
Pharmaceutics
·
29
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
2023
·
Wenjiao Yang
, Xudong Gong
, et al.
·
European Journal of Medicinal Chemistry
·
20
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats
2022
·
Congke Zhao
, Liqing Hu
, et al.
·
Vascular Pharmacology
·
20
Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
2022
·
Yi-fei He
, Yin Liu
, et al.
·
Acta Pharmacologica Sinica
·
19
Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models
2024
·
Guangzhao Shu
, Yang He
, et al.
·
Neuroscience Letters
·
18
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
2021
·
Hongjie Qian
, Qian Chen
, et al.
·
Drug Design Development and Therapy
·
14
PDF
Structural basis for repurpose and design of nucleoside drugs for treating COVID-19
2020
·
Wanchao Yin
, Xiaodong Luan
, et al.
·
bioRxiv (Cold Spring Harbor Laboratory)
·
12
PDF
Efficient Large-Scale Process for Tecovirimat via Reactive Distillation for the Preparation of Cycloheptatriene
2023
·
Emmanuel Mintah Bonku
, Hongjian Qin
, et al.
·
Organic Process Research & Development
·
11
F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution
2024
·
Qian Zhang
, Wenhai Yin
, et al.
·
Journal of Medicinal Chemistry
·
7
PDF
Impurity study of tecovirimat
2024
·
Emmanuel Mintah Bonku
, Hongjian Qin
, et al.
·
Heliyon
·
6
In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others
2024
·
Junjun Mao
, Feifei Yu
, et al.
·
Frontiers in Pharmacology
·
5
PDF
Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer
2024
·
Rulei Yang
, Yiran Liu
, et al.
·
Pharmaceutics
·
5
PDF
Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV -2
2024
·
Samuel Desta Guma
, Zhaoyin Zhou
, et al.
·
European Journal of Medicinal Chemistry
·
4
Efficacy and safety of simenafil in men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel group, phase 3 trial
2025
·
Yuzhuo Yang
, Xiansheng Zhang
, et al.
·
The Journal of Sexual Medicine
·
3
Efficacy and safety of simenafil in men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel group, phase 2 trial
2026
·
Yuzhuo Yang
, Tao Jiang
, et al.
·
The Journal of Sexual Medicine
·
2
Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
2025
·
Samuel Desta Guma
, Kang Song
, et al.
·
Bioorganic & Medicinal Chemistry
·
2
A Phase 1 Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment
2025
·
Ping Fu
, Yi Song
, et al.
·
Clinical Pharmacology in Drug Development
·
2
PDF
Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects
2025
·
Jie Cheng
, Hongjie Qian
, et al.
·
Clinical and Translational Science
·
2
PDF
Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine
2025
·
Yan Cheng
, Davlat Akramov
, et al.
·
Journal of Natural Products
·
2
The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia
2024
·
Jiaxin Cheng
, Chunhui Wu
, et al.
·
Pharmacology Biochemistry and Behavior
·
2
Design, synthesis, and evaluation of novel tricyclononene carboxamide derivatives as dual anti-orthopoxvirus and anti-inflammatory agents
2026
·
Tengxiao Sun
, Wei Zheng
, et al.
·
Bioorganic & Medicinal Chemistry
·
1
Pharmacokinetic Drug Interactions of TPN171 When Coadministration With Rifampicin or Itraconazole
2025
·
Liyu Liang
, Haiping Qin
, et al.
·
Clinical Therapeutics
·
1
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Works count:
34
Citation count:
883
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