Science Farm Ltd. (Japan)

Alternate names: Science Farm, Science Farm Ltd., サイエンスファーム株式会社

ROR: 040d8pq63

OpenAlex ID: I4405275631

Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases

2020 · Aliaa M. Mohassab, Heba A. Hassan, et al. · Bioorganic Chemistry · 130

Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors

2019 · Belgin Sever, Mehlika Dilek Altıntop, et al. · European Journal of Medicinal Chemistry · 124

Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis

2022 · Belgin Sever, Halilibrahim Ciftci, et al. · International Journal of Molecular Sciences · 82

A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication

2024 · Belgin Sever, Masami Otsuka, et al. · International Journal of Molecular Sciences · 73

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In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors

2020 · Belgin Sever, Mehlika Dilek Altıntop, et al. · Molecules · 57

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Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020

2021 · Eslam Roshdy, Muhamad Mustafa, et al. · European Journal of Medicinal Chemistry · 48

Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

2019 · Nilüfer Bayrak, Hatice Yıldırım, et al. · Bioorganic Chemistry · 40

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

2019 · Halil I. Ciftci, Mohamed O. Radwan, et al. · Molecules · 37

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New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study

2021 · Aliaa M. Mohassab, Heba A. Hassan, et al. · Journal of Molecular Structure · 34

Discovery and structure–activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells

2019 · Halil I. Ciftci, Nilüfer Bayrak, et al. · Archiv der Pharmazie · 34

Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs

2021 · Halil I. Ciftci, Nilüfer Bayrak, et al. · Bioorganic Chemistry · 33

Design, Synthesis, and Mechanistic Anticancer Evaluation of New Pyrimidine-Tethered Compounds

2025 · Farida Reymova, Belgin Sever, et al. · Pharmaceuticals · 31

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EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy

2021 · Halil I. Ciftci, Mohamed O. Radwan, et al. · International Journal of Molecular Sciences · 31

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Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

2019 · Mohamed O. Radwan, Halil I. Ciftci, et al. · Molecules · 30

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Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs

2021 · Nilüfer Bayrak, Halil I. Ciftci, et al. · Chemico-Biological Interactions · 28

A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity

2019 · Nilüfer Bayrak, Hatice Yıldırım, et al. · Chemical Biology & Drug Design · 28

Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source "Turkish DeLight"

2023 · Necati Atalay, Enver Kamil Akcan, et al. · TURKISH JOURNAL OF BIOLOGY · 27

Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity

2020 · Halil I. Ciftci, Mustafa Can, et al. · Investigational New Drugs · 27

Anti-cancer activity of the cell membrane-permeable phytic acid prodrug

2019 · Takuya Masunaga, Naoki Murao, et al. · Bioorganic Chemistry · 26

New SIRT2 inhibitors: Histidine-based bleomycin spin-off

2019 · Taha F.S. Ali, Halil I. Ciftci, et al. · Bioorganic & Medicinal Chemistry · 25

Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors

2023 · Mohamed O. Radwan, Sultan F. Kadasah, et al. · Biomolecules · 24

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Minimum structural requirements for inhibitors of the zinc finger protein TRAF6

2019 · Mohamed O. Radwan, Ryoko Koga, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Design and synthesis of new quinoline-ester/-amide derivatives as potent antiproliferative agent targeting EGFR and BRAFV600E kinases

2023 · Aliaa  M. Mohassab, Heba  A. Hassan, et al. · Journal of Molecular Structure · 21

Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia

2025 · Ayca Irgit, Reyhan Kamıs, et al. · Archiv der Pharmazie · 20

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Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction

2022 · Nafia Gökçe Ulusoy, Safiye Emirdağ, et al. · International Journal of Biological Macromolecules · 20

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Works count: 104

Citation count: 3,262