Rational Drug Design Laboratories (Japan)

Alternate names: Rational Drug Design Laboratories, 創薬技術研究所

ROR: 00gqkt134

OpenAlex ID: I4405282813

Surface of bacteriorhodopsin revealed by high-resolution electron crystallography

1997 · Yoshiaki Kimura, Dmitry G. Vassylyev, et al. · Nature · 476

ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2

2010 · K. Chono, K. Katsumata, et al. · Journal of Antimicrobial Chemotherapy · 171

Effect of the Extra N-terminal Methionine Residue on the Stability and Folding of Recombinant α-Lactalbumin Expressed in Escherichia coli

1999 · Tapan K. Chaudhuri, Katsunori Horii, et al. · Journal of Molecular Biology · 103

Novel Hepatitis C Virus Protease Inhibitors: Thiazolidine Derivatives

1997 · Kenji Sudo, Yukiharu Matsumoto, et al. · Biochemical and Biophysical Research Communications · 102

Inhibitory Effects of Podophyllotoxin Derivatives on Herpes Simplex Virus Replication

1998 · K Sudo, K Konno, et al. · Antiviral chemistry & chemotherapy · 72

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Crystal Structure of Anti-Hen Egg White Lysozyme Antibody (HyHEL-10) Fv-Antigen Complex

1999 · Hidemasa Kondo, Mitsunori Shiroishi, et al. · Journal of Biological Chemistry · 69

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A Potent Aldose Reductase Inhibitor, (2S,4S)-6-Fluoro-2‘,5‘-dioxospiro[chroman-4,4‘-imidazolidine]-2-carboxamide (Fidarestat): Its Absolute Configuration and Interactions with the Aldose Reductase by X-ray Crystallography

2000 · Mitsuru Oka, Yukiharu Matsumoto, et al. · Journal of Medicinal Chemistry · 68

MTT colorimetric assay system for the screening of anti-orthomyxo- and anti-paramyxoviral agents

1994 · W. Watanabe, K. Konno, et al. · Journal of Virological Methods · 64

Human Follicular Dendritic Cells Remain Uninfected and Capture Human Immunodeficiency Virus Type 1 through CD54-CD11a Interaction

1999 · Masatoshi Fujiwara, Rikiya Tsunoda, et al. · Journal of Virology · 52

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Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A

1999 · Tadashi Mizuta, Masatoshi Fujiwara, et al. · Nature Biotechnology · 50

A sensitive assay system screening antiviral compounds against herpes simplex virus type 1 and type 2

1994 · Kenji Sudo, Kenji Konno, et al. · Journal of Virological Methods · 50

Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells

1999 · Masatoshi Fujiwara, Mika Okamoto, et al. · Antiviral Research · 45

Discovery of anti-influenza A virus activity of a corynanthe-type indole alkaloid, hirsutine, in vitro and the structure-activity relationship of natural and synthetic analogs

1997 · Hiromitsu Takayama, Yasuo Iimura, et al. · Bioorganic & Medicinal Chemistry Letters · 45

Use of lactate dehydrogenase to evaluate the anti-viral activity against influenza A virus

1995 · Wataru Watanabe, Kenji Sudo, et al. · Journal of Virological Methods · 42

Structural Evidence for Entropic Contribution of Salt Bridge Formation to a Protein Antigen-Antibody Interaction

2001 · Mitsunori Shiroishi, Akiko Yokota, et al. · Journal of Biological Chemistry · 40

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Establishment of an in vitro assay system for screening hepatitis C virus protease inhibitors using high performance liquid chromatography

1996 · Kenji Sudo, Hiroshi Inoue, et al. · Antiviral Research · 37

Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in HB611 Cells

1994 · T. Yokota, K. Konno, et al. · Antiviral chemistry & chemotherapy · 32

Utilization of wieland furoxan synthesis for preparation of 4-aryl-1,2,5-oxadiazole-3-yl carbamate derivatives having potent anti-HIV activity

1996 · Hiromitsu Takayama, Seiichiro Shirakawa, et al. · Bioorganic & Medicinal Chemistry Letters · 31

Ingenol Derivatives are Highly Potent and Selective Inhibitors of HIV Replication in Vitro

1996 · M. Fujiwara, K. Ijichi, et al. · Antiviral chemistry & chemotherapy · 29

Mouse Model of Respiratory Syncytial Virus Infection to Evaluate Antiviral Activity in Vivo

1999 · Kenji Sudo, Wataru Watanabe, et al. · Antiviral chemistry & chemotherapy · 28

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Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives

1998 · M. Fujiwara, M. Okamoto, et al. · Archives of Virology · 28

Antisense therapy of influenza

2001 · Takayuki Abe, Tadashi Mizuta, et al. · European Journal of Pharmaceutical Sciences · 27

Identification of Two Nucleotide-Binding Domains on the PB1 Subunit of Influenza Virus RNA Polymerase

1997 · Y. Asano, A. Ishihama · The Journal of Biochemistry · 26

Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides

1998 · Takayuki Abe, Kazuyuki Takai, et al. · FEBS Letters · 25

Novel Hepatitis C virus Protease Inhibitors: 2,4,6-Trihydroxy,3-Nitro-Benzamide Derivatives

1997 · K Sudo, Y Matsumoto, et al. · Antiviral chemistry & chemotherapy · 25

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Works count: 72

Citation count: 6,830