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Institute for Theoretical Medicine (Japan)
Alternate names:
Institute for Theoretical Medicine, Inc.,
理論創薬研究所
ROR:
025x5ka86
OpenAlex ID:
I4405283729
Structure–activity relationships of the thujaplicins for inhibition of human tyrosinase
2014
·
Atsushi Yoshimori
, Takahiro Oyama
, et al.
·
Bioorganic & Medicinal Chemistry
·
57
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells
2018
·
Shoma Tamori
, Yuka Nozaki
, et al.
·
Oncotarget
·
49
PDF
Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models
2020
·
Atsushi Yoshimori
, Yasunobu Asawa
, et al.
·
ChemMedChem
·
48
PDF
The structural differences between mushroom and human tyrosinase cleared by investigating the inhibitory activities of stilbenes
2022
·
Takahiro Oyama
, Atsushi Yoshimori
, et al.
·
Journal of Molecular Structure
·
41
Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer
2017
·
Yuka Nozaki
, Shoma Tamori
, et al.
·
Genes & Cancer
·
40
PDF
Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors
2016
·
Takahiro Oyama
, Satoshi Takahashi
, et al.
·
Bioorganic & Medicinal Chemistry
·
40
Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses
2019
·
Kenya Tamada
, Shingo Nakajima
, et al.
·
Biochemical and Biophysical Research Communications
·
36
Antitumor activity of potent pyruvate dehydrogenase kinase 4 inhibitors from plants in pancreatic cancer
2019
·
Yukihiro Tambe
, Tokio Terado
, et al.
·
Molecular Carcinogenesis
·
32
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth
2019
·
Takayuki Yamamoto
, Akira Sato
, et al.
·
Biochemistry and Biophysics Reports
·
31
PDF
Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO
2007
·
Atsushi Yoshimori
, Junichi Sakai
, et al.
·
BMC Pharmacology
·
30
PDF
Strategies for Design of Molecular Structures with a Desired Pharmacophore Using Deep Reinforcement Learning
2020
·
Atsushi Yoshimori
, Enzo Kawasaki
, et al.
·
Chemical and Pharmaceutical Bulletin
·
29
PDF
Integrating the Structure–Activity Relationship Matrix Method with Molecular Grid Maps and Activity Landscape Models for Medicinal Chemistry Applications
2019
·
Atsushi Yoshimori
, Toru Tanoue
, et al.
·
ACS Omega
·
28
A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models
2017
·
Hiroshi Ueda
, Jun-ichi Kurita
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
27
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins
2010
·
Satoshi Takahashi
, Takanori Kamiya
, et al.
·
Bioorganic & Medicinal Chemistry
·
26
TLSC702, a Novel Inhibitor of Human Glyoxalase I, Induces Apoptosis in Tumor Cells
2016
·
Ryoko Takasawa
, Nami Shimada
, et al.
·
Biological and Pharmaceutical Bulletin
·
25
PDF
Prediction of Molecular Properties Using Molecular Topographic Map
2021
·
Atsushi Yoshimori
·
Molecules
·
23
PDF
Approach for the Design of Covalent Protein Kinase Inhibitors via Focused Deep Generative Modeling
2022
·
Atsushi Yoshimori
, Filip Miljković
, et al.
·
Molecules
·
20
PDF
Deep SAR matrix: SAR matrix expansion for advanced analog design using deep learning architectures
2020
·
Atsushi Yoshimori
, Jürgen Bajorath
·
Future Drug Discovery
·
18
PDF
Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors
2019
·
Yasunobu Asawa
, Kiyotaka Katsuragi
, et al.
·
Bioorganic & Medicinal Chemistry
·
16
Structural insight into the active site of mushroom tyrosinase using phenylbenzoic acid derivatives
2017
·
Takahiro Oyama
, Atsushi Yoshimori
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
16
Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach
2021
·
Rohmad Yudi Utomo
, Yasunobu Asawa
, et al.
·
Bioorganic & Medicinal Chemistry
·
15
PDF
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors
2020
·
Sei-ichi Tanuma
, Kiyotaka Katsuragi
, et al.
·
Molecules
·
15
PDF
Deep learning driven de novo drug design based on gastric proton pump structures
2023
·
Kazuhiro Abe
, Mami Ozako
, et al.
·
Communications Biology
·
14
PDF
Motif2Mol: Prediction of New Active Compounds Based on Sequence Motifs of Ligand Binding Sites in Proteins Using a Biochemical Language Model
2023
·
Atsushi Yoshimori
, Jürgen Bajorath
·
Biomolecules
·
14
PDF
Synthesis of Three‐Dimensional (Di)Azatricyclododecene Scaffold and Its Application to Peptidomimetics
2021
·
Kohei Umedera
, Taiki Morita
, et al.
·
Chemistry - A European Journal
·
13
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Works count:
69
Citation count:
1,289
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