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TYK Medicines, Inc.
Homepage:
tykmedicines.com
Alternate names:
TYK Medicines,
同源康医药,
浙江同源康医药股份有限公司
ROR:
02pz3ch87
OpenAlex ID:
I4405283994
Ceritinib is a novel triple negative breast cancer therapeutic agent
2022
·
Shengli Dong
, Hassan Yousefi
, et al.
·
Molecular Cancer
·
39
Photochemical difluoromethylation of alkynes: synthesis of CF 2 H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines
2023
·
Xiaoyu Chen
, Yang Geng
, et al.
·
Organic Chemistry Frontiers
·
23
Cyclin-dependent kinase 4 and 6 inhibitors in breast cancer treatment
2025
·
Zhengfei Guo
, Richard W. Dong
, et al.
·
Oncogene
·
18
Cu‐Catalyzed C−H Perfluoroalkylation/Cyclization of Unactivated Alkenes: Synthesis of Perfluoroalkylated Tricyclimidazoles
2022
·
Zhuangzhuang Guo
, Xiaoyu Chen
, et al.
·
Advanced Synthesis & Catalysis
·
15
Visible‐Light‐Induced Direct C−H Amination of Quinoxalin‐2(1H)‐ones
2022
·
Yanpeng Liu
, Congcong Pei
, et al.
·
Advanced Synthesis & Catalysis
·
13
Visible-light-induced trifluoromethylation/cyclization of unactivated alkenes: Synthesis of CF3-substituted fused tricyclic indoles
2024
·
Jialong Jiao
, Yang Geng
, et al.
·
Tetrahedron Letters
·
11
Iron‐Catalyzed Direct C3−H Trifluoromethylthiolation of Quinoxalin‐2(1H)‐ones
2023
·
Xiaoyu Chen
, Yang Geng
, et al.
·
Advanced Synthesis & Catalysis
·
10
Visible‐Light‐Induced Multicomponent Reaction of Aromatic Aldehydes, Amines and Sodium Difluoromethanesulfinate: Synthesis of CF2H‐Substituted Secondary Amines
2023
·
Shanshan Zhang
, Yang Geng
, et al.
·
Advanced Synthesis & Catalysis
·
9
Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy
2023
·
Shengli Dong
, Margarite D. Matossian
, et al.
·
Scientific Reports
·
9
PDF
Visible‐Light‐Induced Oxidative Carboazidation of Arylacrylamides
2023
·
Congcong Pei
, Yanpeng Liu
, et al.
·
Advanced Synthesis & Catalysis
·
8
PDF
Photoredox-Catalyzed Radical Cascade Cyclization of N -Cyanamide Alkenes with N -Aminopyridinium Salts: Modular Synthesis of Polycyclic Quinazolinones
2025
·
Zhiwei Xu
, Yuting Leng
, et al.
·
The Journal of Organic Chemistry
·
6
Silver-mediated radical cascade trifluoromethylthiolation/cyclization of benzimidazole derivatives with AgSCF 3
2024
·
Pan Liu
, Yang Geng
, et al.
·
Organic & Biomolecular Chemistry
·
6
Metabolism and pharmacokinetic study of deuterated osimertinib
2023
·
Xuyi Zhan
, Shaoyin Bao
, et al.
·
Biopharmaceutics & Drug Disposition
·
6
Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy
2024
·
Shengli Dong
, Suresh K. Alahari
·
Frontiers in Cell and Developmental Biology
·
5
PDF
Safety, Pharmacokinetics, and Efficacy of Asandeutertinib in Advanced EGFR-mutated NSCLC: A Phase 1 Dose-Escalation and Dose-Expansion Study
2025
·
Baohui Han
, Jie Liu
, et al.
·
Journal of Thoracic Oncology
·
3
Visible-light-induced radical trifluoromethylation/cyclization of alkynes: synthesis of CF 3 -containing dioxodibenzothiazepines
2025
·
Xiaoyu Chen
, Yang Geng
, et al.
·
Organic & Biomolecular Chemistry
·
3
MA08.06 Comparison of Asandeutertinib and Osimertinib in EGFR-Mutated NSCLC With Brain Metastases: Interim Analysis of the ESAONA Pivotal Study
2025
·
Y. Shi
, L. Xing
, et al.
·
Journal of Thoracic Oncology
·
2
A phase II study of asandeutertinib (TY-9591) in advanced NSCLC patients with EGFR-positive mutations and brain metastases.
2025
·
Pu-Yuan Xing
, Ligang Xing
, et al.
·
Journal of Clinical Oncology
·
2
PDF
Photoredox catalyzed three-component tandem cyclization of 1,5-dienes with α-keto acids and water to access pyrrolidinones
2025
·
Kaixia Sui
, Shiliang Jiang
, et al.
·
Chemical Communications
·
2
Photocatalytic cyclization reaction of 2-vinylarylamines with CF 3 SO 2 Na and arylaldehydes to access 3-(2,2,2-trifluoroethyl)-3 H -indoles
2025
·
Mengda Song
, Yuting Leng
, et al.
·
Chemical Communications
·
1
Photocatalytic Cascade Cyclization of Unactivated Alkenes With N ‐Aminopyridinium Salts Toward Tetrahydropyridazine and Dihydropyrazole Derivatives
2026
·
Mengna Li
, Yuting Leng
, et al.
·
Asian Journal of Organic Chemistry
PDF
Nischarin interaction with LGR4 mediates the suppression of the Wnt/β-catenin signaling pathway
2026
·
Shengli Dong
, Steven Eastlack
, et al.
·
European Journal of Cell Biology
Editorial: New drugs and future challenges in drug metabolism and transport
2026
·
Maja Đanić
, Charles Oo
, et al.
·
Frontiers in Pharmacology
PDF
Efficacy and safety of asandeutertinib versus osimertinib as first-line treatment in EGFR-mutated NSCLC patients with brain metastases: Interim analysis of an open-label, multicenter, randomized, pivotal phase II study (ESAONA).
2026
·
Yuankai Shi
, Ligang Xing
, et al.
·
Journal of Clinical Oncology
Abstract 6494: The selective YAP/TEAD inhibitor TY-1054 enhances the efficacy of KRAS inhibitors or Trop2-ADC in multiple solid tumors
2026
·
Shengli Dong
, Zhengfei Guo
, et al.
·
Cancer Research
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Works count:
35
Citation count:
409
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