Dietary Modulation of the Dynamics between Leukocyte Inflammation, Cholesterol Flux, and HDL function in Metabolic Syndrome
Year: 2013
Type: dissertation
Abstract: Obesity is associated with dysfunctional lipoproteins, low-grade inflammation, and an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM).HDL and leukocytes play well documented roles in chronic disease development, whereas HDLleukocyte interactions further modify cellular cholesterol flux and inflammatory potential.Therefore, therapeutic strategies that alter HDL-leukocyte dynamics may have profound effects on obesity-related disease progression.We investigated the modulation of HDL-leukocyte dynamics by a dietary intervention known to favorably affect HDL metabolism and inflammation in metabolic syndrome (MetS) -a population at increased risk for CVD and T2DM.Thirty-seven men and women classified with MetS consumed a moderate carbohydrate-restricted diet in addition to either 3 whole eggs per day (EGG) or the equivalent amount of egg substitute (SUB) for 12 weeks.Egg yolks are a rich source of highly bioavailable, bioactive phospholipids and antioxidant carotenoids.After the 12-week intervention, all subjects increased HDL-cholesteryl ester/triglyceride ratios; however, whole egg intake resulted in enrichment of HDL in phosphatidylethanolamine and egg yolk-derived sphingomyelin species.The cholesterol-Chapter 5: Egg intake during carbohydrate restriction alters the inflammatory potential of peripheral blood mononuclear cells in metabolic syndromex
Author: Catherine J. Andersen
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W102813246