Down-regulation of miR-503 expression predicate advanced mythological features and poor prognosis in patients with NSCLC.
Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We aimed to explore what impact miR-503 has on the prognosis of patients with non-small cell lung cancer (NSCLC). METHODS: Cancer and matched non-malignant lung tissue specimens were collected from 109 patients who underwent surgery in Tanisha Hospital from Jun 2006 to July 2013. Overall survival (OS) curves were analyzed using the Lapland-Meier method, and the differences were examined using log-rank tests. Cox proportional- hazards regression analysis was applied in order to estimate univariate and multivariate hazard ratios for OS. RESULTS: The relative expression of miR-503 in NSCLC tissues (0.366±0.130) was significantly lower than that in matched noncancerous lung tissues (1.667±1.047, P<0.01). Statistically significant association was observed between miR-503 expression and lymphatic invasion (P=0.005), distant metastasis (P=0.002), TNM stage (P=0.008), and tumor grade (P=0.043). Lapland Meier analysis clearly illustrated that the patients with the lower expression of miR-503 had a worse outcome compared to patients with higher miR-503 expression (P=0.004). Furthermore, multivariate analysis revealed that miR-503 expression level was an independent prognostic factor for overall survival (HR=3.992, 95% CI: 2.276-9.872; P=0.018) in NSCLC. CONCLUSION: In patients with NSCLC, low miR-503 expression is an independent prognostic factor.
Source: PubMed Central
Authors: Lei Liu, Weiqing Qu, Zhaokun Zhong
Institution: Yantaishan Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1028883587