Fibromialgia: utilità terapeutica di un antidepressivo NaSSA (mirtazapina)
Year: 2006
Type: article
Study design: Clinical Trial
Abstract: PainFibromyalgiaMirtazapine • ImipramineClomipramin Summary Fibromyalgia is a chronic, non-articular form of rheumatism, characterised by wide- spread muscular pain and painful sensitivity to pressure applied at the designated tender points (Fig. 1). The aetiology of this pathological condition remains unclear, the principal symptoms are muscular rigidity and pain in various muscles of the body, frequently related mental disorders include anxiety and depression. While therapy with non-steroidal anti-inflammatory drugs has not been effective, antidepressants have led to better results. The purpose of this study was to evaluate the efficacy of treatment based on mirtazapine, a Noradrenergic and Selective Serotoninergic Anti- depressant (NaSSA), on 24 fibromyalgia patients. After twelve weeks of treatment, 15 patients (62.5%) showed a significant improvement in relation to pain, fatigue, sleep disturbances and depression. Seven patients (29.1%) had better Visual Analog Scale (VAS) results in relation to pain and sleep disturbances but not in relation to fatigue, and had only limited Hamilton Depression Rating Scale (HDRS) improvement. Two patients (8.3%) had withdrawn from treatment because of adverse reactions to the drug (Table I).
Author: T. Vannucchi
Language: Italian
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W102950042