Year: 2009
Type: book-chapter
Abstract: Protein acetylation is involved in the regulation of several cellular functions such as protein-protein interactions, protein stability, and DNA recognition by proteins.For instance, the acetylation of histone proteins alters gene transcription [1].Thus, removal of acetyl groups from lysine residues results in compaction of chromatin and, hence, repression of gene transcription.The process of acetylation and deacetylation regulated by proteins with acetyltransferase activity is important for cellular processes.These proteins are usually known as histone acetyltransferases [2].Nowadays, there is a growing interest for histone deacetylases (HDACs) because of their potential clinical applications [3].HDACs have been divided into four groups.Class I and class II HDACs are similar to the yeast Rpd3p and Hda1p proteins.Class III HDACs are similar to the yeast transcriptional repressor Sir2p and are referred to as sirtuins.Class I and class II HDACs are characterized by contents
Source: Oxidative stress and disease
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1030535918