In situ formation of antigen-antibody complexes in the mouse glomerulus.
Year: 1979
Type: article
Abstract: Intravenous administration of heat-aggregated bovine serum albumin (BSA) to mice resulted in localization of micro-particulate BSA in the mesangial region of the glomerulus. Subsequent intravenous administration of rabbit anti-BSA antibody at a time when no free antigen remained in the circulation produced localization of antibody and fixation of mouse complement within the glomerulus in a pattern corresponding to that of the heat-aggregated BSA. This apparent in situ formation of immune complexes in the glomerulus is similar to that of the classical Arthus phenomenon in the skin.
Source: PubMed
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W103243359