Year: 2015
Type: article
Abstract: Understanding the learning behavior of brain functional connectivity within motor sequence learning of foot tapping tasks is of great importance to help improving walking quality of elderly people. It is also of great interest to clinical and scientific communities. The role of functional connectivity in brain function has not yet been well understood. This study comprises of two parts; the first part is to investigate brain signal stationarity, while the other will look into brain interactions while performing motor learning sequence task. Functional magnetic resonance imaging (fMRI) was utilized to acquire data from twelve healthy adult participants to study brain functional connectivity and interactions during a sequence of motor learning foot tapping tasks. Tasks were divided into: two different learning blocks, two control blocks, and five blocks of resting states. In this condition, 90 percent of the subjects developed awareness of the sequence. The stationarity of fMRI time series needs to be understood as it has important implications on the choice of appropriate approaches for the analysis of complex brain networks. The reverse arrangement test RAT was utilized to investigate the time series stationarity. Our analysis showed some non-stationary signals with a time varying first moment as a major source of non-stationarity. Next, we choose to apply psycho-physiological interactions (PPI) approach to our data and we revealed some information about the degree to which components of large-scale neural systems were functionally coupled together to achieve and perform the designed learning sequence task. In this work, we will introduce the idea of psycho-physiological interaction (PPI), which explains the responses in one cortical region in terms of an interaction between the effects of other regions and learning task parameter. We have found that the Thalamus was mostly involved and modulated with our predesigned motor learning task. We also found that the Middle frontal Gyrus and Left pre-central Gyrus were the most interacting regions with the above mentioned cluster. This interaction can only be related to the interactions that are based on the experimental factors which are the psychological and physiological interactions. The current results have also supported PPI as a potential tool for understanding learning mechanism during foot tapping tasks.
Author: Othman Muhei-aldin
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funder: National Institute on Aging
OpenAlex ID: W1037454217