Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant
Year: 2004
Type: article
Study design: Observational Study
Abstract: Purpose:This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants. Methods:Interleukin-1β(IL-1β), Interleukin-6(IL-6), Tumor necrosis factor-α(TNF-α) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records. Results:Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group. Conclusion:Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-α & IL-1β in this study.
Source: Korean Journal of Pediatrics
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1038843305