Serum Visfatin in Type II Diabetes Mellitus and Its Implication in Development of Diabetic Complications
Year: 2014
Type: article
Study design: Observational Study
Abstract: Background: Diabetes mellitus is a multifactorial disease that is characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia in diabetes is associated with long-term complications, including micro vascular disease such as retinopathy, nephropathy, neuropathy and macro vascular disease including fatal and non-fatal myocardial infarction and peripheral vascular disease. Excess adiposity is the most important risk in the development of insulin resistance and diabetes mellitus II. Adipose tissue produce several factors called adipokines, visfatin is one of them, it acts as insulin mimetic, rate limiting enzyme in NAD synthesis and pro inflammatory cytokine. The study aims to evaluate serum visfatin level in type II diabeticpatients and elucidate its possible role in development of diabetic complications. Methods: This study was carried out on sixty patients with type II diabetes mellitus. They are classified into two groups according to the presence of complications or not. Group I: included fifteen patients with uncomplicated type II diabetes mellitus. Group II: included forty five Patients with complicated diabetes mellitus, divided according to the type of complication into three subgroups as following: with cardiovascular complications, with diabetic nephropathy and with diabetic foot respectively. Each subgroup included fifteen patients. In addition, fifteen clinically healthy subjects were recruited as control group. All studied subjects were subjected to complete medical history, clinical examination and routine laboratory investigations including fasting serum glucose level, post prandial serum level, serum creatinine, lipid profile and complete urine analysis, serum nitric oxide levels and serum visfatin by ELISA. Results: the study revealed that: § Serum visfatin levels were significantly elevated in diabetic patients (complicated & uncomplicated) compared to healthy control subjects. § Serum visfatin levels were significantly decreased in patients with cardiovascular complications and diabetic foot compared to uncomplicated group. § Visfatin correlated negatively with HDL in cardiovascular complications and correlate positively with ESR in diabetic foot. It did not correlate with age, BMI, FBS, PP, NO, cholesterol, TG, LDL or creatinine. § A significant decrease in serum nitrite in uncomplicated, cardiovascular complications and diabetic nephropathy groups but non-significant decrease in diabetic foot group compared to control group. § A significant increase in serum nitrite in cardiovascular complications & diabetic foot compared to uncomplicated group. § A significant decrease in serum nitrite in cardiovascular complications & diabetic nephropathy compared to diabetic foot group. Conclusions: Visfatin andnitrite may have a role on diabetes pathophysiology. Serum visfatin levels reduced with insulin treatment in complicated type II diabetes mellitus patients.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1049657010