Work

Can Sir(2) regulate cancer?

Year: 2008

Type: article

Abstract: Sirtuin activators, including small molecules such as polyphenols and resveratrol, are much desired due to their potential to ameliorate metabolic disorder and delay or prevent aging. In contrast, recent studies demonstrate that targeted silencing of sirtuin 1 (SIRT1) expression or activity by the deleted in breast cancer 1 (DBC1) may be beneficial by promoting p53-induced apoptosis in cancer cells, and by sensitizing cancerous cells to radiation therapy. Negative SIRT1 regulation also alleviates gene-repression associated with fragile X mental retardation syndrome. The targeted activation or inhibition of SIRT1 activity therefore emerges as a critical point of regulation in disease pathogenesis.

Source: PubMed

Authors: Pratibha V Nerurkar, Vivek R Nerurkar

Institutions: University of Hawaiʻi at Mānoa, University of Hawaii System

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Research Resources, National Institute on Minority Health and Health Disparities, National Center for Complementary and Integrative Health

Awards: RCMI CLINICAL RESEARCH INFRASTRUCTURE INITIATIVE (RCRII), Bioscience Research Infrastructure Development for Grant Enhancement and Success, Longevity foods, SIRT activation and diabetic dyslipidemia., The Center for Native and Pacific Health Disparities Research