Distinct breast cancer subtypes in women with early-onset disease across races.
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Racial disparities among breast cancer (BCa) patients are known but not well studied in early-onset BCa. We analyzed molecular subtypes in early-onset BCa across five major races. METHODS: A total of 2120 cases were included from non-Hispanic White (NHW), African American (AA) and Hispanic, Chinese and Indian. Based on ER, PR and HER-2 status, BCa was classified into 4 intrinsic subtypes as Luminal A, Luminal B, HER2/neu overexpression and Triple negative BCa (TNBC) subtypes. Data was stratified according to race and age as younger/early-onset group (40-years and younger) and older group (50-years and older). RESULTS: In early-onset BCa, incidence of TNBC was significantly higher (p = 0.0369) in Indian women followed by AA, Hispanic, NHW and Chinese women. Incidence of Her2 over-expression subtype also was highest in Indian women, followed by Hispanic, Chinese, AA and NHW women. In contrast, Luminal B subtype was most significantly higher in AA women (p = 0.0000) followed by NHW (p = 0.0002), Chinese (p = 0.0003), Hispanic (0.0128) and Indian (p = 0.0468) women. Luminal A subtype was most significantly reduced in Indian women (p = 0.0113) followed by Hispanic, AA, NHW and Chinese women. These results were based on statistical analysis with the mean of older group populations. CONCLUSIONS: These results show significant disparities in receptor subtypes across races. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for early-onset BCa patients.
Source: Europe PMC (PubMed Central)
Authors: Mandeep Singh, Yi Ding, Li-Ying Zhang, Dong Song, Yun Gong, Sylvia Adams, Dara S Ross, Jin-Hua Wang, Shruti Grover, Dinesh Chandra Doval, Charles Shao, Zi-Li He, Victor Chang, Warren W Chin, Fang-Ming Deng, Baljit Singh, David Zhang, Ru-Liang Xu, Peng Lee
Institutions: Rajiv Gandhi Cancer Institute and Research Centre, New York University, Memorial Sloan Kettering Cancer Center, First Hospital of Jilin University, The University of Texas MD Anderson Cancer Center, State University of New York, SUNY Downstate Health Sciences University, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W111163211